Post-doctoral (or graduate student) position in structural biology of parasite motility
We are looking for a post-doctoral fellow for a 2.5-year project (possible extension for up to 1 year) in my group at the Faculty of Biochemistry and Molecular Medicine (FBMM), University of Oulu, Finland. Alternatively, an exceptionally highly-qualified PhD student could be considered. The overall aim of my group is to understand the molecular mechanism of malaria parasite gliding motility. To reach this goal, we use a wide variety of structural biology and biochemical/biophysical methods. Our ongoing work is focused on (i) the polymerization and ATPase mechanism of actin, (ii) parasite actomyosin complexes, (iii) the structure and function of the glideosome-associated linker protein, and (iv) reconstructing the entire membrane-delimited motor complex in vitro for structural and functional studies. The exact project will be agreed upon based on the experience and interests of the successful candidate.
Main content
The candidate should have a PhD (or MSc if applying for a graduate student position) in a relevant field of science and have experience, or at least a keen interest, in all or several of the following:
- molecular biology and protein expression and purification
- biophysical and biochemical characterization of proteins and their complexes
- protein crystallography and/or cryo-EM
- light and/or electron microscopy
We welcome applications particularly from candidates willing and eligible to apply for competitive funding from national, European, and international sources.
Our research group is split between the FBMM in Oulu and the Department of Biomedicine, University of Bergen, Norway. Our laboratories and the available core facilities available have state-of-the-art equipment for molecular biology, protein biochemistry/biophysics, and electron and light microscopy. We have active collaborations for cryo-EM and cell biology/parasitology.
The project is funded by the Sigrid Jus茅lius foundation, and the candidate will receive a personal stipend (tax-exempt up to the limit defined by the Finnish tax authorities and subject to a compulsory pension insurance).
Informal inquiries and applications including a motivation letter, a CV with publication list, and contact information for 2-3 referees are to be sent to inari.kursula@oulu.fi. Applications will be considered until a suitable candidate has been identified. The starting date is as soon as possible.
Publications most relevant for the project:
Pires I, Hung YF, Bergmann U, Molloy JE &聽Kursula I聽(2022) Analysis of聽Plasmodium falciparum聽myosin B ATPase activity and structure in complex聽with the calmodulin-like domain of its light chain MLC-B.聽J Biol Chem聽in press,
Vahokoski J, Calder L, Lopez AJ, Molloy JE,聽Kursula I聽&聽Rosenthal PB (2022) High-resolution structures of malaria parasite actomyosin and actin filaments. PLoS Pathog聽18: e1010408.
Kumpula EP, Lopez AJ, Tajedin L, Han H & Kursula I (2020) Atomic view into聽Plasmodium聽actin polymerization, ATP hydrolysis, and fragmentation.聽PLoS Biol聽17: e3000315.
Kumpula EP, Pires IP, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J &聽Kursula I聽(2017) Apicomplexan actin polymerization depends on nucleation.聽Sci Rep聽7: 12137.
Pospich S, Kumpula EP, von der Ecken J, Vahokoski J,聽Kursula I聽& Raunser S (2017) Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability.聽Proc Natl Acad Sci USA聽114: 10636-10641.
Jacot D, Tosetti N, Pires IP, Stock J, Graindorge A, Hung YF, Han H, Tewari R,聽Kursula I聽& Soldati-Favre D (2016)聽An apicomplexan actin-binding protein serves as a connector and lipid sensor to coordinate motility and invasion.聽Cell Host Microbe聽20: 731-743.
More info:
Group webpages in and Bergen