Our publications
Here are some key publications from our work.
Main content
For a full list, see听听辞谤 Inari's page.
Selected publications:
Hung YF, Chen Q, Pires I, Han H, Rosenthal PB & Kursula I (2023) Structure of Toxoplasma gondii glideosome-associated connector suggests a role as an elastic element in actomyosin force generation for gliding motility. Preprint available on bioRxiv: .
Dans MG, Piirainen H, Nguyen W, Khurana S, Mehra S, Razook Z, Geoghegan ND, Dawson AT, Das S, Schneider MP, Jonsdottir TK, Gabriela M, Gancheva MR, Tonkin C, Mollard V, Goodman CD, McFadden GI, Wilson DW, Rogers KL, Barry AE, Crabb BS, de-Koning-Ward TF,听Sleebs BE,听Kursula I听& Gilson PR (2023)听The sulfonylpiperazine MMV020291 prevents red blood cell invasion by the malaria parasite听Plasmodium falciparum听through interference with actin-1/profilin dynamics.听PLoS Biol听21:听别3002066.
Lopez AJ, Andreadaki M, Vahokoski J, Deligianni E, Calder LJ, Camerini S, Freitag A, Bergmann U, Rosenthal PB, Sid茅n-Kiamos I & Kursula I (2023) Structure and function of Plasmodium actin II in the parasite mosquito stages. PLoS Pathog听19:听别1011174.
Pires I, Hung YF, Bergmann U, Molloy JE &听Kursula I听(2022) Analysis of听Plasmodium falciparum听myosin B ATPase activity and structure in complex听with the calmodulin-like domain of its light chain MLC-B.听J Biol Chem听298: 102634.
Vahokoski J, Calder L, Lopez AJ, Molloy JE,听Kursula I听&听Rosenthal PB (2022) High-resolution structures of malaria parasite actomyosin and actin filaments. PLoS Pathog听18: e1010408.
Bendes 脕脕, Kursula P &听Kursula I听(2022) Structure and function of an atypical homodimeric actin capping protein from the malaria parasite. Cell Mol Life Sci 79: 125.
Moreau CA, Quadt KA, Piirainen H, Kumar H, Bhargav SP, Strauss L, Tolja NH, Wade RC, Spatz JP,听Kursula I听& Frischknecht F (2020) Optical tweezers uncover a function of profilin in force generation during malaria parasite motility independent of actin binding.听J Cell Sci听134: jcs233775.
Kumpula EP, Lopez AJ, Tajedin L, Han H & Kursula I (2019) Atomic view into听Plasmodium听actin polymerization, ATP hydrolysis, and fragmentation.听PLoS Biol听17: e3000315.
Mukherjee B, Tessaro F, Vahokoski J,听Kursula I, Marq JB, Scapozza L & Soldati-Favre D (2018) Modeling and resistant alleles explain the selectivity of compound 49c towards apicomplexan aspartyl proteases.听EMBO J听37: e98047.
Pino P, Caldelari R, Mukherjee B, Vahokoski J, Klages N, Maco B, Collins CR,听Kursula I, Blackman MJ, Heussler V, Brochet M & Soldati-Favre D (2017) A multi-stage antiplasmodial targets the plasmepsins IX and X essential for invasion and egress.听Science听358: 522-528.
Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE,听Kursula I, Tewari R & Holder AA (2017) Compositional and expression analyses of the glideosome during the听Plasmodiumlife cycle reveal an additional myosin light chain required for maximum motility.听J Biol Chem听292: 17857-17875.
Kumpula EP, Pires IP, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J &听Kursula I听(2017) Apicomplexan actin polymerization depends on nucleation.听Sci Rep听7: 12137.
Pospich S, Kumpula EP, von der Ecken J, Vahokoski J,听Kursula I听& Raunser S (2017) Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability.听Proc Natl Acad Sci听114: 10636-10641.
Moreau C, Bhargav SP, Kumar H, Quadt KA, Piirainen H, Strauss L, Kehrer J, Streichfuss M, Spatz J, Wade R,听Kursula I听& Frischknecht F (2017) A unique profilin-actin interface is important for malaria parasite motility.听PLoS Pathog听13: e1006412.
Jacot D, Tosetti N, Pires IP, Stock J, Graindorge A, Hung YF, Han H, Tewari R,听Kursula I听& Soldati-Favre D (2016)听An apicomplexan actin-binding protein serves as a connector and lipid sensor to coordinate motility and invasion.听Cell Host Microbe听20: 731-743.
Mueller C, Samoo A, Hammoudi PM, Klages N, Kallio JP,听Kursula I听& Soldati-Favre D (2016) Structural and functional dissection of听Toxoplasma gondii听armadillo repeats only protein.听J Cell Sci听129: 1031-1045.
Bhargav SP, Vahokoski J, Kallio JP, Torda A, Kursula P &听Kursula I听(2015) Two independently folding units of听Plasmodium听profilin suggest evolution听via听gene fusion.听Cell Mol Life Sci听72: 4193-4203.
Salamun J, Kallio JP, Daher W, Soldati-Favre D &听Kursula I听(2014) Structure of听Toxoplasma gondii听coronin 鈥� an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress.听FASEB J听28: 4729-4747.
Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP,听Mu帽ico Martinez S,听Ignatev A, Lepper S, Frischknecht F, Sid茅n-Kiamos I, Sachse C &听Kursula I听(2014) Structural differences explain diverse functions of听Plasmodium听actins.听PLoS Pathog听10: e1004091.
Singh BK, Sattler JM, Chatterjee M, Huttu J, Sch眉ler H &听Kursula I听(2011) Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite.听J Biol Chem听286: 28256-28264.
Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K & Sch眉ler H (2008) Structural basis for parasite鈥恠pecific functions of the divergent profilin of听Plasmodium falciparum.听Structure听16: 1638-1648.