Jean Paul Thiery
Professor Jean Paul Thiery is a well-known researcher within the听field of cancer therapeutics. Until July听2015 he was professor and head of the听Department of Biochemistry of the听Yong Loo Lin School of Medicine at the听National University of Singapore (NUS).听He also held a research director position听at IMCB A*STAR and has been director听of research at the Center National de la听Recherche Scientifique (CNRS), Paris. Currently, he is a senior scientist at the Bioland Laboratory, Guangzhou, China, in addition to his affiliation to CCBIO.
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From 1995 to 2003, Professor Thiery established听and headed the Cell Biology Department听of the Institut Curie. Professor Thiery has听made seminal contributions in the fields of听cell adhesion, cell migration, morphogenesis听and cancer, publishing more than 470听peer-reviewed articles in different areas of听the life sciences.听His influential works include pioneering studies in cell adhesion and migration in early embryogenesis and in elucidating the roles of growth factors and adhesion signaling molecules in Epithelial-Mesenchymal Transitions (EMT). Jean Paul Thiery is credited to be the first to propose that EMT controls carcinoma cell invasion and dissemination. Currently, his research focuses on oncogenomics and the creation of functional approaches to characterize bladder and lung carcinoma progression with the goal to apply EMT-based therapeutic approaches.
At CCBIO, Professor Thiery is听collaborating听with Professor James Lorens to unravel听mechanisms driving immune escape in听solid tumors. He is exploring the role of听epithelial mesenchymal transition in carcinoma听in the formation of defective immunological听synapse. Together with Professor听Lorens and colleagues, Professor Thiery is听conducting experiments to assess the role听of Axl tyrosine kinase in driving resistance听of mesenchymal-like carcinoma cells to听cytotoxic T lymphocyte lysis.
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