Research groups
Across the different core programs, several areas of research and specific projects have been initiated at CCBIO, focusing on mechanisms of tumor-microenvironment interactions and tumor progress, discovery and validation of tumor biomarkers, and clinical studies.
Main content
CCBIO聽has 4 research teams and programs:
Team 1: Mechanisms of Tumor-Microenvironment Interactions
- CCBIO PI聽Donald Gullberg聽聽聽 PubMed p
- CCBIO PI聽Karl H. Kalland聽聽聽 PubMed
- CCBIO PI Emmet McCormack聽 PubMed s
The aim of this program is to examine how tumor聽cells interact with the surrounding and supporting聽microenvironment with different cell types such聽as fibroblasts, immune cells, vascular cells and聽stem cells embedded in the complex extracellular聽matrix. This team consists of the Principal聽Investigators McCormack, Kalland and Gullberg (photo)聽and their groups.
Team 2: Discovery of聽Cancer Biomarkers
- CCBIO PI and Director聽Lars A. Akslen聽聽 PubMed
- CCBIO PI聽James B. Lorens 聽聽 PubMed
- CCBIO Associate Investigator Camilla Krakstad聽 PubMed
- CCBIO Associate Investigator Daniela Elena Costea聽 PubMed
- CCBIO Associate Investigator Elisabeth Wik聽 听笔耻产惭别诲
- CCBIO Associate Investigator Carina Strell聽 聽 PubMed
- CCBIO Associate Investigator Agnete Engelsen聽 聽 听笔耻产惭别诲
The aim of this program is to explore and validate different classes聽of biomarkers in tissue samples from human patient cohorts and聽clinical trials material. Currently, the investigators take advantage of the聽recently established technology of IMC (imaging mass cytometry) by which聽panels of multiple biomarkers are simultaneously linked to specific tissue聽compartments in parallel with functional interrogation. The studies also聽map associations with clinico-pathologic phenotypes as well as prognostic聽and potentially predictive properties. This team consists of the Principal聽Investigators Akslen (CCBIO director) and Lorens and their groups, and聽the Associate Investigators Costea, Krakstad, Wik, Strell and Engelsen (Lorens, Strell and Engelsen not present in the photo).
Team 3: Clinical Applications and Trial Studies
- CCBIO PI and Co-Director聽Bj酶rn T. Gjertsen聽聽 PubMed
- CCBIO PI聽Oddbj酶rn Straume聽聽聽 PubMed
- CCBIO PI聽Line Bj酶rge聽 听笔耻产惭别诲
The aim of this program is to perform clinical聽trials with associated biomarker studies, and to聽promote novel findings on markers and treatment聽targets for clinical implementation and change of聽practice. This team consists of the Principal聽Investigators Straume, Gjertsen (CCBIO co-director) and Associate Investigator Bj酶rge.
Team 4: Health Ethics, Prioritization and Economics
- CCBIO PI聽Roger Strand (ethics)聽 听笔耻产惭别诲
- CCBIO Associate Investigator聽John Cairns (health economics)
- CCBIO Associate Investigator Ole Frithjof Norheim (prioritization)
The aim of this program is to perform studies on聽the ethics, economics and priority challenges of the聽biomarker field, to contribute towards improved聽education of CCBIO scientists in this dimension聽of their work, and to ultimately influence public聽debate and policy making in the expanding area聽of biomarkers and targeted therapy. This team聽consists of Principal Investigator Strand, as well as聽Associate Investigators Norheim and Cairns.
In addition, Bioinformatics is an important intersecting research area at聽CCBIO:
- CCBIO Associate Investigator聽Inge Jonassen (bioinformatics)聽听笔耻产惭别诲