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Charalampos Tzoulis
Department of Clinical Medicine, University of Bergen

Accumulated mitochondrial DNA (mtDNA) damage is implicated in both aging and specific neurodegenerative diseases such as Parkinson’s disease (PD). In our recent work, we show that the impact of mitochondrial DNA deletions in PD substantia nigra neurons is mediated through a failure to compensate by increasing mtDNA copy number. Our findings suggest that dysregulation of mtDNA homeostasis is a key process in the pathogenesis of neuronal loss in Parkinson’s disease.

Chairperson: Arvid Lundervold, Department of Biomedicine