Consequences of night shift simulation on waking performance, sleep, circadian rhythmicity and brain function
Main content
We live in a 24h society where a range of services are required around the clock. As a result, millions of people worldwide are working at times when the body is tuned to sleep. Night shift work is associated with impaired waking function and increased risk of accidents during work hours. There are also negative health effects associated with night shift work, such as sleep problems, metabolic syndrome, cardiac disease and certain types of cancer.
The Bergen Stress and Sleep group and collaborators work translationally to study the effects of simulated night shift work on waking performance, sleep, circadian rhythmicity, metabolic measures and molecular markers of brain function. We also investigate ways to counter these negative effects, particularly how light of different intensity and color quality impact on waking performance and brain function.
The project includes both human and animal experiments. We aim to find out how simulated night shift work and different light conditions affect:
- Sleep quality and length
- Waking function (alertness and cognitive performance)
- Circadian rhythmicity
- Brain function and protein synthesis
- Energy intake and expenditure
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Publications from this project
听Pedersen TT, Sunde E, Wisor J, Mrdalj J, Pallesen S, Gr酶nli J.听Nat Sci Sleep, 2022,听14:243-254
听听Sunde E, Mrdalj J, Pedersen TT, Bjorvatn B, Gr酶nli J, Harris A, Waage S, Pallesen S.听Chronobiol Int, 2022,听39(7):948-963
听Marti AR, Pedersen T, Wisor JP, Mrdalj J, Holmelid 脴, Patil S, Meerlo P, Bramham CR, Gr酶nli J.听Sci Rep, 2020, 10(1), 13141.
听Sunde E, Pedersen T, Mrdalj J, Thun E, Gr酶nli J, Harris A, Bjorvatn, B, Waage S, Skene DJ, Pallesen S. Clocks Sleep, 2020, 2(4): 502-522.
听Sunde E, Pedersen T, Mrdalj J, Thun E, Gr酶nli J, Harris A, Bjorvatn, B, Waage S, Skene DJ, Pallesen S.听Front Psychol, 2020,听 11, 2172.
听Sunde E, Mrdalj J, Pedersen T, Thun E, Bjorvatn B, Gr酶nli J, Harris A, Waage S, Pallesen S.听Occup Environ Med, 2020,听77(4), 249-255.
听Gr酶nli J, Mrdalj J.听The Journal of physiology, 2018,听596(12):2269-2270.
Marti AR, Patil S, Mrdalj J, Meerlo P, Skrede S, Pallesen S, Pedersen TT, Bramham CR, Gr酶nli J. Frontiers in Neural Circuits, 2017 11(70). doi: 10.3389/fncir.2017.00070.
Gr酶nli J, Meerlo P, Pedersen TT, Pallesen S, Skrede S, Marti AR, Wisor JP, Murison R, Henriksen TEG, Rempe MJ, Mrdalj J. J Biol Rhythm, 2017 Feb;32(1):48-63. doi: 10.1177/0748730416675460.
Marti AR, Meerlo P, Gr酶nli J, van Hasselt SJ, Mrdalj J, Pallesen S, Pedersen TT, Henriksen TEG, Skrede S. Nutrients, 2016 Nov 8;8(11). doi:10.3390/nu8110712
听Rempe MJ, Gr酶nli J, Pedersen TT, Mrdalj J, Marti AR, Meerlo P, Wisor JP. Neurobiology of Sleep and Circadian Rhythms, 2018,听5:37-51
Doctoral degrees
Andrea R酶rvik Marti.听Shift work, circadian rhythms, and the brain. Identifying biological mechanisms underlying the metabolic and cognitive consequences of work timing, using a rat model.听Link for听.
Erlend Sunde.听Effects of light interventions for adaptation to night work. Simulated night work experiments.听Link for听.听
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Master degrees
Robin Bjorheim.听Daytime sleep after simulated night shift work, a polysomnographic study of the impact of working in blue-enriched and red-enriched narrow-bandwidth light
Anna Elfrida Hovde Vollsund.听The relationship between shift work, sleep disturbances and oxidative stress in the brain
Maiken Birkelid. Modeling night shift work and gastrointestinal function
脴ystein Holmelid. Simulated Night Work, Sleep-Wake Changes and Markers of Brain Plasticity
Josien Janssen. Effects of simulated night shift work on circadian rhythmicity of body temperature
Andrea R酶rvik Marti. Circadian and metabolic consequences of shift work -a rat model
Torhild Pedersen. Night work and disturbances in sleep- an animal model