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University of Bergen

Translational Protein Research

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The eukaryotic NAT-machinery

Protein N-terminal acetylation

From molecular mechanisms to human disease

Most proteins are聽chemically modified in聽the cell聽and such modifications are often crucial for the protein鈥檚 ability to carry out a聽function. N-terminal acetylation one of the most common modifications in eukaryotes. It is catalyzed by N-terminal acetyltransferases (NATs) which are聽linked to cancer, genetic syndromes, and regulation of human metabolism.

Translational Protein Research group (Arnesen lab) is part of the Systems Biology and Translational Cell Signaling聽research unit at the Department of biomedicine.

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ADO versus NatA

Improved understanding of oxygen sensors in human cells

Oxygen is vital for human life and so is our ability to respond to low oxygen levels. Researchers at the University of Oxford and University of Bergen have uncovered new factors defining how human cells respond to hypoxia.

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Bildet viser en CT scan av en person med hjerneforkalkning

Shedding new light on brain calcification

Brain calcification can cause movement disorders and cognitive impairment. New research by the Arnesen Lab at 幸运飞艇计划 provides increased insight into how these calcifications occur.

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Figur 1, se bildetekst for mer informasjon

幸运飞艇计划 researchers solve protein mystery

Researchers from the University of Bergen (幸运飞艇计划) have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.

New research
Impact of N-terminal acetylation in yeast

Removing protein N-terminal acetylation increases the turnover of ribosomal proteins

The impact of the most common protein modification, N-terminal acetylation, has remained a conundrum in the field since its very origin. A new 幸运飞艇计划 article adds a piece to this puzzle.