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In a new article recently published in Developmental Biology, researchers from former Sars associate group led by (Institute of Basic Medical Science, University of Oslo) have described the coordinated calcium signaling that occurs during development in the tunicate Oikopleura dioica. Tunicates provide an excellent system to study calcium signaling during formation and maturation of the embryo听thanks to their rapid development,听small size, and evolutionary proximity to vertebrates.

In a , authors Oleg Tolstenkov, now a researcher in the Chatzigeorgiou Group, and Yana Mikhaleva, a staff engineer at the Department of clinical medicine, University of Bergen, investigated this process in the early phase of Oikopleura dioica鈥檚 embryonic development, up to the gastrulation stage. They showed that during this early period, calcium signals spread as coordinated听waves throughout the embryo, passing through gap junctions between the early embryonic cells.听In their latest study, they听extended their observations to the less studied post-gastrulation period, when the different tissues and organs of the animal鈥檚 body are established. 鈥�No one has followed听calcium signaling in听developing听Oikopleura听before,"听explains first author Oleg Toltsenkov, 鈥渁nd the more models we use to describe this process, the easier it becomes to find general rules among animals.鈥�

Once tissues and organs start to form in the small tunicate, the calcium waves that spread throughout the embryo at earlier stages still exist but originate from different places and spread in more organ-specific patterns. In particular, waves start in the central nervous system before spreading to the developed musculature. Using drugs that disrupt synaptic transmission, the authors showed that this sequence of calcium signals travels via synaptic connections. This pattern is like the neural control of movement that occurs during behavior in fully developed organisms.

It is fascinating that the nervous system starts adopting this leading role so early on in development. We do not know yet the role of these calcium waves, but we can imagine that they are important for synchronizing the different mechanisms at play during development.

Oleg Tolstenkov

With this exciting follow-up paper, the team completed a full chart of the way calcium signals are orchestrated through the entire developmental period in听Oikopleura, from the unfertilized egg to the behaving larva. In the future, this information can help decipher the mechanisms that control the transition from whole body waves to organ-specific signaling, and how these different patterns of calcium signaling influence the development of the different tissues in the body. 鈥�Oikopleura is a challenging model system, I learned a lot during this study鈥�, Oleg explains. With the tunicate鈥檚 phylogenetic position, these findings also hit close to home: Oikopleura has the potential to help us understand how the relationship between听calcium signaling and development has evolved in the听lineage that gave rise to vertebrates.