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Up to a third of Norwegian children have enamel defects. A damaged enamel makes the tooth more porous, and more prone to caries and cavities, and for some, enamel defects lead to major dental health problems. A recent Norwegian study has tried to look at the causes of why so many Norwegian children get enamel defects.

A collaborative study between the University of Bergen, Norway, The Weizmann Institute of Science, Israel, and international partners have now shown that about half of children with celiac disease have enamel damage:

鈥淭his is the first time it is shown that enamel damage can be caused by an autoimmune disease, autoimmune amelogenesis imperfect鈥�, explains professor Eystein Husebye at the Department of Clinical Science.

Autoimmune reaction to a common protein in milk

In celiac patients, the research team found a link between autoantibodies to the milk protein kappa-casein and enamel damage:

鈥淚t may seem that in the same way as celiac patients react to gluten in the diet and get intestinal damage, they react to kappa-casein in cow鈥檚 milk and get tooth damage,鈥� says Husebye.

Enables earlier diagnosis.

The other condition with autoimmune enamel damage that was studied is the very rare and hereditary disease autoimmune polyendocrine syndrome type I (APS-I) that affects children.聽

It was the widespread enamel damage in this disease that put the research team in Bergen led by Anette Wolff and Eystein Husebye on the idea that autoimmunity was the cause:

鈥淭he new findings will help us to diagnose celiac disease at an earlier stage and thus prevent enamel damage鈥�, says Huesbye. It also makes it possible finding a 鈥渃ure鈥� for these damages in children:

鈥淚f possible, removing kappa-casein from the diet can prevent enamel damage. In addition, the findings make it possible to consider whether there are similar mechanisms for enamel damage in other diseases鈥�, says professor Husebye.

笔耻产濒颈肠补迟颈辞苍:听.