News archive for Translational Cell Signaling and Metabolism
Recently, researchers in TSG found that Ncp-M1 blocks the liver-specific transporter proteins OATP1B1/OATP1B3. These transporters are responsible for hepatocellular uptake of growth-stimulating steroids, several drugs, and toxins like microcystin, and are an important part of the detoxification machinery of the liver. Ncp-M1 is non-toxic to both liver cells and other cell types, and its mechanism... Read more
Stroke patients have particular high risk of thrombotic events caused by platelet (thrombocyte) activation, which may lead to new infarctions. Secondary treatment of these patients with anti-platelet therapy consisting of aspirin and dipyridamole is therefore a common protocol. Recent results on the mechanism of action of this treatment suggest that regulation of platelet shape change, the... Read more
Neuroblastoma cells are typically arrested at an early and immature stage. The stage of neuroblastoma tumor cell differentiation is known to influence patient outcome, with a high differentiation stage correlating to favorable prognosis.
The mechanisms of cancer cell drug resistance is still not fully understood.
The Translational Signaling Group has through professor Stein Ove D酶skeland expanded our contribution of selected articles by "The Faculty of 1000".
These publications are resulting from ongoing collaboration with research groups in Denmark and Germany.
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