幸运飞艇计划

Background

Medical student, 幸运飞艇计划
Enlisted in The Medical Student Research Program, Faculty of Medicine, 幸运飞艇计划

Project

Melanoma is the most lethal form of skin cancer with 200 000 incidences each year globally, and a mortality rate of about 65 000 a year.听Of cancers that metastasize to the brain, melanoma is the third most common cancer to do so after lung and breast cancer, and has an average survival of less than 9 months.

The mitogen-activated protein kinase (MAPK) pathway is the most commonly mutated pathway in melanoma.听People treated听with BRAF and MEK inhibitors often show relapse of the disease. The resistance is often mediated by pathway reactivation through SRC-family kinase (SFK) signaling or mutant NRAS.听CCT196969 is a paradox-breaking pan RAF inhibitor, targeting simultaneously RAF and SFKs. 听By targeting pan RAF and SFKs, CCT196969 have demonstrated听efficacious inhibitory activity towards MEK/ERK in BRAF and NRAS mutant melanoma. The effects of the drug on brain metastasis have听to our knowledge not been tested previously.

The main aim of my project is to study the effects of CCT196969 on several human brain metastasis cell lines, harboring the BRAF听mutation.听